Items tagged with: develop

- #Scientists #develop 10-minute #universal #cancer #test

Inexpensive procedure shows whether patient has cancerous cells in the body, but does not reveal where or how serious it is

Israeli scientists develop tissue implants that won't be rejected

Breakthrough development uses a patient's own stomach cells, cutting the risk of an immune response to implanted organs.
Article word count: 519

HN Discussion: https://news.ycombinator.com/item?id=18488360
Posted by evo_9 (karma: 42048)
Post stats: Points: 147 - Comments: 13 - 2018-11-19T18:12:57Z

\#HackerNews #develop #implants #israeli #rejected #scientists #that #tissue #wont
Article content:

Israeli researchers report that they have invented the first fully personalized tissue implant, engineered from a patient’s own materials and cells. The new technology makes it possible to engineer any kind of tissue implant, for the spinal cord, to the heart, or brain, from one small fatty tissue biopsy.

“We were able to create a personalized hydrogel from the materials of the biopsy, to differentiate fatty tissue cells into different cell types and to engineer cardiac, spinal cord, cortical and other tissue implants to treat different diseases,” said lead researcher Prof. Tal Dvir of Tel Aviv University’s Center for Nanoscience and Nanotechnology and Sagol Center for Regenerative Biotechnology.

“Since both the cells and the material used derive from the patient, the implant does not provoke an immune response, ensuring proper regeneration of the defected organ,” Dvir explained.

The research was conducted by Dvir’s postdoctoral researcher, Reuven Edri, and doctoral students Nadav Noor and Idan Gal, in collaboration with Prof. Dan Peer and Prof. Irit Gat Viks of TAU’s Department of Cell Research and Immunology and Prof. Lior Heller of Assaf HaRofeh Medical Center in Israel. It was [1]recently published in the journal Advanced Materials.

Avoiding anti-rejection drugs

Currently, in tissue engineering for regenerative medicine, cells are isolated from the patient and cultured in biomaterials to assemble into a functional tissue. These biomaterials can be synthetic or natural, derived from plants or animals.

After transplantation, they may induce an immune response that leads to rejection of the implanted tissue. Patients receiving engineered tissues or any other implants are treated with immuno-suppressors, which unfortunately can endanger the health of the patient.

The new method solves that problem.

“With our technology, we can engineer any tissue type, and after transplantation we can efficiently regenerate any diseased or injured organ — a heart after a heart attack, a brain after trauma or with Parkinson’s disease, a spinal cord after injury,” said Dvir.

“In addition, we can engineer adipogenic [fatty tissue] implants for reconstructive surgeries or cosmetics. These implants will not be rejected by the body.”

The researchers extracted a small biopsy of fatty tissue from patients, then separated its cellular and a-cellular materials. While the cells were reprogrammed to become induced pluripotent stem cells — able to make cells from all three basic body layers, so they can potentially produce any cell or tissue the body needs to repair itself — the extracellular material was processed to become a personalized hydrogel.

After combining the resulting stem cells and the hydrogel, the scientists successfully engineered the personalized tissue samples and tested the patients’ immune responses to them.

The researchers are currently engaged in regenerating an injured spinal cord and an infarcted heart with spinal-cord and cardiac implants. They have also begun to investigate the potential of human dopaminergic implants to treat Parkinson’s disease in animal models.

The researchers plan to regenerate other organs, including intestines and eyes, using the patients’ own materials and cells.

“We believe that the technology of engineering fully personalized tissue implants of any type will allow us to regenerate any organ with a minimal risk of immune response,” Dvir said.


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1. https://onlinelibrary.wiley.com/doi/10.1002/adma.201803895

HackerNewsBot debug: Calculated post rank: 102 - Loop: 243 - Rank min: 100 - Author rank: 51
- #China #Recruits #Patriotic #Children to #Develop Its #AI #Weapons

China believes the children are the future — of its autonomous weapons program.
The ‘Other’ Cappuccino: Researchers Develop Alternative To Cocoa Powder For High-Street Coffees
#cappuccino #researchers #develop #alternative #cocoa #powder #coffees
This may be why some #kids #develop #scoliosis

The body’s inability to fully utilize the essential dietary mineral manganese might be to blame for some cases of severe scoliosis, according to a new study.
- #Scientist #Develop Novel #Biofuel #Refinery #Process that Uses #Marine #Yeast

Bioethanol is gaining currency as a viable energy production option thanks to the work of researchers like the team at the University of Nottingham.
- #Scientists #Develop the Most #Wear-Resistant #Metal Alloy in the #World

Researchers at the famed Sandia National Laboratories have developed a platinum-gold alloy that withstands high amounts of heat and friction.
- #Scientists #Develop #Unique #Materials To #Repair #Damaged #Organs And #Tissue

Tissue engineering is the future of medicine. Under Project 5-100, the Polymer Materials for Tissue Engineering and Transplantology Laboratory of Peter the Great St. Petersburg Polytechnic University (SPbPU) created unique polymeric materials for medical purposes that repair traumatized human organs.
Es gibt nun auch #redis .. sorry wegen dem durcheinander auf #develop ...
Auch für meinen Geschmack etwas zu viel Mastodon und zu wenig vom Rest der #Föderation - aber trotzdem ein informativer Talk und sehr empfehlenswert:
Vortrag über dezentrale und soziale Netzwerke #gpn

Alles sehr Mastodon lastig, aber doch recht interessant. Auch #pleroma findet Erwähnung. :)
#federation #mastodon #pleroma #activitypub #develop
Willkommen dann auf #develop, dem Wild-Wild-West ... ;-)

Poller cron job reports error

The latest #develop code reports a problem started by poller.php:
PHP Warning: Invalid argument supplied for foreach() in /home/.../public_html/friendica/include/poller.php on line 208
PHP Stack trace:
PHP 1. {main}() /home/.../public_html/friendica/include/poller.php:0
PHP 2. poller_run() /home/.../public_html/friendica/include/poller.php:265
PHP 3. poller_kill_stale_workers() /home/.../public_html/friendica/include/poller.php:58

Maybe again some better variable tests? And I saw a message this #friendica installation is having problems, several hits on F5 (reload) key brought it back again.
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